AIST AssoTosse - Ricerca

A Randomized Clinical Trial Comparing the Effects of Antitussive Agents on Respiratory Center Output in Patients With Chronic Cough.

Chest. 2017 Jun

Author: Mannini C, Lavorini F, Zanasi A, Saibene F, Lanata L, Fontana G.

Abstract

BACKGROUND:

Cough is produced by the same neuronal pool implicated in respiratory rhythm generation, and antitussive drugs acting at the central level, such as opioids, may depress ventilation. Levodropropizine is classified as a nonopioid peripherally acting antitussive drug that acts at the level of airway sensory nerves. However, the lack of a central action by levodropropizine remains to be fully established. We set out to compare the effects of levodropropizine and the opioid antitussive agent dihydrocodeine on the respiratory responses to a conventional CO₂ rebreathing test in patients with chronic cough of any origin.

A reappraisal of the mucoactive activity and clinical efficacy of bromhexine

Multidiscip Respir Med. 2017

Authors: Zanasi Alessandro, Mazzolini Massimiliano, Kantar Ahmad

Abstract

Since its introduction to the market in 1963, bromhexine, an over-the-counter drug, has been investigated for its activity in animal models and in humans with diverse respiratory conditions.

Bronchodilator therapy for chronic cough

Pulm Pharmacol Ther. 2017

Authors: Matera Maria Gabriella, Rogliani Paola, Zanasi Alessandro, Cazzola Mario

Abstract

Experimental studies indicate that airway calibre increases the sensitivity of the afferents involved in the cough reflex but it has proved difficult to demonstrate that airway calibre increases the sensitivity of the afferents involved in the cough reflex.

Survey on attitudes of Italian pediatricians toward cough

Clinicoecon Outcomes Res. 2017

Author: Zanasi A, Morcaldi L, Cazzato S, Mazzolini M, Lecchi M, Morselli-Labate AM, Mastroroberto M, Dal Negro RW.

Abstract

CONTEXT:

Children's cough is a daily concern for most pediatricians. The management of both acute and chronic cough requires a systematic and comprehensive approach. Despite the approved protocols for management, the pediatric assessment of cough and the corresponding prescribing attitude frequently do not fit these protocols, which can be affected by parental suggestions - sometimes substantially.